In a large bowl, mix together the ground beef, breadcrumbs, chopped onion, beaten egg, milk, Worcestershire sauce, garlic powder, salt, and pepper until well combined.
Shape the meat mixture into a loaf and place it in the crockpot.
In a small bowl, whisk together the ketchup, brown sugar, and mustard to make the topping. Spread the topping over the meatloaf.
Cover and cook on low for 6-7 hours, or until the meatloaf is fully cooked.
Let the meatloaf rest for 10 minutes before slicing and serving.
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